WHO finalizes MDR-TB treatment guidance recommending shift from injections

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Including recommendations that injected drugs with permanent debilitating side effects not be included in longer treatment regimens against multidrug-resistant tuberculosis, and the inclusion of the most recently added drugs, bedaquiline and delamanid in those treatments, the World Health Organization today released updated guidelines for treating TB that does not respond to first line treatments. The […]

CUGH 2019: Researchers say training, resources for the “private sector,” including traditional healers, will be critical to TB control

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CHICAGO – To find the missing tuberculosis cases that go unreported each year, national TB programs will have to reach out to the places where the most people seek care, researchers said here. And that’s not in public hospitals or clinics where capacities to respond to TB already exist, but in the private sector in […]

STREAM Trial: Nine-month regimen for drug-resistant tuberculosis brings “promising cure rates”

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A randomized, multi-country clinical trial testing a regimen for treating drug-resistant tuberculosis in less than a year against the up to two-year regimen recommended by the World Health Organization in 2011 guidelines, substantiates earlier observed findings showing comparable success rates between the two. The STREAM trial (Standard Treatment Regimen of Anti-Tuberculosis drugs for patients with […]

WHO releases updated drug-resistant TB guidelines, removing toxic injectables from recommended treatments

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With the release of a “pre-final text” of updated guidelines for treatment of multidrug- and rifampicin-resistant tuberculosis, the World Health Organization made official substantial changes to its recommendations that the agency first announced in August. The changes, announced in a “rapid communication,” which the WHO said was intended to give TB programs time to plan for […]

49th Union World Conference on Lung Health: 90 percent of participants in short-course XDR-TB regimen cured after six months

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THE HAGUE, Netherlands – New results from the ongoing Nix-TB trial continue to confirm a short-course treatment regimen of bedaquiline – one of the two newest drugs to treat TB in half a century – linezolid and pretomanid offers a significantly improved treatment option for people infected with drug resistant forms of tuberculosis, researchers said […]

49th Union World Conference on Lung Health: Integrating HIV treatment and TB preventative therapy greatly improves IPT adherence

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THE HAGUE, Netherlands – When tuberculosis preventive therapy is delivered with HIV treatment services and patients get a choice in where they access treatment, completion of tuberculosis preventive therapy rises, helping to ensure people living with HIV stay healthy, researchers said here. This model of prevention should be scaled up in TB-HIV high burden settings, researchers […]

49th Union World Conference on Lung Health: Activists call for price drop on MDR-TB drug

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THE HAGUE, Netherlands – Attendees here observed a minute of silence on Thursday in remembrance of an 18-year-old girl in India who died two weeks ago from multidrug-resistant tuberculosis. She died, treatment advocates explained, because she couldn’t access bedaquiline, a drug that received regulatory approval five years before she needed it. Among attendees here joining the […]

49th Union World Conference on Lung Health: Private provider engagement led to 10-fold increase in Mumbai TB case detection

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THE HAGUE, Netherlands – In Mumbai, the largest city in the world’s highest TB burden country, more than half of people living with active tuberculosis disease go undetected and undiagnosed every year. Much of the failure to adequately detect TB cases stems from a dependence on the private sector for health care – more than […]

49th Union World Conference on Lung Health: GeneXpert can test stool samples to accurately diagnose TB in children

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THE HAGUE, Netherlands – Tuberculosis in children — disease that responds to first line treatment, as well as drug-resistant strains — can be accurately diagnosed by using existing GeneXpert machines and cartridges to test stool samples for TB bacteria, researchers announced here. Not only can GeneXpert accurately diagnose TB and drug resistance in a fraction of […]

49th Union World Conference on Lung Health: Study shows scaling up TB prevention in children is possible

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THE HAGUE, Netherlands – Children – especially very young children – are at high risk of developing severe tuberculosis illness when exposed to a member of their household who has active disease, but only 23 percent of child contacts of adults with active disease are provided with TB preventive therapy, researchers said here. That leaves 1.3 […]