Study shows revaccination with existing TB vaccine prevents TB infection later in life

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Getting revaccinated later in life with the same vaccine given to infants to prevent tuberculosis may provide additional protection after the original vaccine loses efficacy, researchers at the 5th Global Forum on TB Vaccines in New Delhi, India, revealed. The Bacillus Calmette–Guérin, or BCG, vaccine is partially effective against preventing TB infection in children for […]

Study indicates that acting on guidelines could avert half of TB cases among children

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Tracing contacts of people confirmed to be sick with tuberculosis and making preventive treatment available to those at risk for the disease, could halve current numbers of TB cases among children in resource limited settings, according to researchers reporting a study of patients across a Kenya rural province. Both of those steps are recommended by […]

Findings indicate two newest TB drugs, bedaquiline and delamanid in combination safe, promising for patients with few options

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A study following outcomes of 28 patients with drug-resistant tuberculosis in three countries with high burdens of the disease found what the researchers cite as strong evidence that a combination of the two newest TB drugs could be part of a safe and effective treatment regimen. The  drugs, bedaquiline — which was approved by the […]

Comprehensive care and support significantly boosts MDR-TB successful treatment completion

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A Taiwan program of comprehensive support and care centered on the needs of patients being treated for multidrug-resistant tuberculosis — at a cost of from $25,000 to $30,000 per patient, per year over the costs of medicines — substantially improved cure rates and drastically reduced rates of patients whose outcomes were unknown, according to a […]

Antiretroviral treatment with treatment for drug-resistant TB evens odds for people with HIV

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People living with HIV achieve rates of survival from drug-resistant tuberculosis similar to those of people without the virus, when they receive immediate access to antiretroviral medicine along with their tuberculosis treatment, a study following more than 200 patients in South Africa found. The findings, pointing to the critical benefits of “aggressive initiation” of life-saving […]

Study reveals biological processes leading to active tuberculosis disease

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Researchers at the University of Cape Town in South Africa have identified a sequence of biological processes that occur as tuberculosis infection progresses to active pulmonary tuberculosis disease. The findings, which demonstrate a clear timeline of biological events that occur between infection and disease, hold important implications for the development of new diagnostics, treatments, and […]

Stigma surrounding tuberculosis keeps patients from services, worsens health risks, but remains largely unmeasured, unaddressed

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Interviews in Kenya, Tanzania and Namibia health facilities found that the more staff knew about patients’ rights, the likelier they were to recognize — and report — discrimination against people with tuberculosis. A study in Lesotho found links between stigma surrounding HIV and TB and increased rates of depression and alcohol use among co-infected patients. […]

48th Union World Conference: Minimally invasive autopsies could fill in the blanks on causes of death

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GUADALAJARA, Mexico – In places where a person can get sick with tuberculosis but never get diagnosed, or get diagnosed, but never treated, with their illness never reported, and where a person can die young without ever coming in contact with a health system, the uncertainties surrounding the true impacts of the TB continue all the […]

48th Union World Conference: In the long path to TB care, competence is among the obstacles

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GUADALAJARA, Mexico – One after another, patients came to clinics and hospitals in rural China complaining of alarming, nagging and debilitating symptoms. They noted  coughs and fevers that didn’t go away, and that they were losing weight for no apparent reason. Their symptoms should have sounded familiar in the health centers of a country with […]

48th Union World Conference: Review finds missed opportunities for preventive therapy for children with HIV in Swaziland

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GUADALAJARA, Mexico – While the vulnerability of children with HIV to tuberculosis has prompted World Health Organization guidelines recommending TB preventive therapy for children with the virus who are over a year old, a review of patient data across 10 years at a Swaziland center providing care to about a fifth of all children with […]