Category Archives: IAS2011ROME

The 6th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, Rome.

TB preventive therapy reduces death, disease among HIV positive patients

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Results from a new study in Brazil show that not only is tuberculosis (TB) preventive treatment safe and effective, but it also shows significant benefits at the community level.

Announced at the 2011 International AIDS Conference in Rome, the THRio (TB and HIV in Rio) study investigators implemented clinical staff training on the importance of preventing TB in people living with HIV, and teaching doctors and nurses how to perform testing for TB infection. Scientists at Rio de Janeiro Municipal Health Secretariat in Brazil and the John Hopkins University studied these interventions in 29 clinics in Rio de Janeiro, including almost 13,000 HIV-positive patients, to determine the impact of isoniazid preventive therapy (IPT) on rates of TB and death in that population.

The intervention had a modest impact (13 percent reduction) on TB, but showed an important and statistically significant impact on TB and death that might be attributed to TB (28 percent reduction)…

HIV and TB Co-Infection: A Perfect Storm

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Alberto Matteeli of Italy began his presentation on HIV and tuberculosis (TB) by reminding his audience that in the pre-antiretroviral therapy (ART) era in Europe and the United States, there were serious outbreaks of drug-resistant tuberculosis, and these outbreaks ceased when ART was scaled up in those settings.  There are currently HIV-associated epidemics of multi-drug […]

HPTN 052 “treatment is prevention” study team releases new details

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The presentation of the detailed findings of HPTN 052 by Dr. Myron Cohen, the study’s principal investigator, and his colleagues was greeted with a standing ovation by a packed room at the 2011 International AIDS Conference in Rome on Monday. The stunning finding of a more than 96 percent reduction in transmission risk for discordant couples where the HIV-infected partner was randomized to early antiretroviral therapy (ART) at CD4 counts of 350-550 compared to couples where ART was delayed for the infected partners until CD4 counts dropped to 250 or less, makes ART the most effective prevention intervention identified to date…