Category Archives: TB

New combo drug trial has potential to transform TB treatment

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In the lead up to World Tuberculosis (TB) Day this Saturday, March 24, the TB Alliance announced the launch of a new trial to test a combination drug regimen in patients with drug-sensitive TB as well as patients with multidrug-resistant (MDR) TB – the first time this has ever been done. Called “NC-002,” the eight-week […]

Blueprint toward a TB-free future

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Plan to develop new vaccines could help stop TB in our children’s lifetimes

The following is a guest blog post by Dr. Lucica Ditiu, executive secretary of the Stop TB Partnership, commenting on the newly released document Tuberculosis Vaccines: A Strategic Blueprint for the Next Decade, reflecting the consensus of members of the TB vaccine research and development community to develop new vaccines that could help stop TB in our children’s lifetimes.

Reichman: “TB has always been ignored and forgotten”

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In advance of World TB Day (Saturday, March 24) Science Speaks sat down with tuberculosis (TB) expert Lee B. Reichman, MD, MPH, founding executive director of the New Jersey Medical School Global Tuberculosis Institute, to discuss the spread of drug-resistant TB and what he thinks are the most promising advances coming down the scientific pipeline. […]

World TB Day Activities

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What do you have planned next week to commemorate World TB Day on March 24? Several organizations and federal agencies are hosting events aimed at raising awareness about global and domestic TB, and what donors are doing to tackle the problem. Although most of these events take place in Washington, DC, some are being simultaneously […]

Community-level preventive TB therapy in South African gold miners fails to bring down overall incidence

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Individuals still saw TB incidence reduction of two-thirds, but effect was not durable

Preliminary results from the Thibela Project – which looked at whether community-wide provision of isoniazid preventive therapy (IPT) in South African gold mines would improve TB control in these high-incidence sites…

Household-based HIV and TB intervention boosts HIV testing, lowers community TB prevalence

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At the 19th Conference on Retroviruses and Opportunistic Infections in Seattle, Dr. Helen Ayles presented some key results on behalf of the ZAMSTAR team from the first randomized trial of a combined HIV and TB intervention strategy to demonstrate a reduction in population prevalence of tuberculosis. The study, conducted in 24 communities in Zambia and […]

High dose of new HIV drug might improve outcomes for HIV/TB co-infected

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Treating patients co-infected with HIV and tuberculosis (TB) can be tricky – as rifampin, a key sterilizing drug in TB regimens – can reduce concentrations of antiretrovirals administered at the same time, as well as other drug-drug complications. Early efforts to combat this phenomenon have unearthed a potential treatment candidate – an increased dose of […]