Tag Archives: bedaquiline

Long road to effective TB treatment hits speed bumps: Regulatory refusal of one TB drug candidate, stalled progress on another

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Momentum toward gathering an effective arsenal of treatment for tuberculosis may have gathered speed in recent years, the 2013 Pipeline Report jointly released by the Treatment Action Group and HIV i-base in June pointed out, yet it falls far short of what people sick and infected with TB worldwide need now. Case in point, the […]

WHO guidance on first new TB treatment in five decades offers hope, emphasizes monitoring

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WHO cites need to prevent new drug resistance, protect first treatment advance in more than 40 years The World Health Organization’s release this week of  interim policy guidelines on the use of bedaquiline  for treatment of multidrug-resistant tuberculosis  offers hope to patients and their physicians running out of options to treat the disease, but the […]

Wrapping up CROI 2013, Part I: TB on the verge, VOICE trial point to future research needs, sequestration consequence points to rough road ahead

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Science Speaks spent March 3 – 6 at the Conference on Retroviruses and Opportunistic Infections, covering breaking research news and discussions. Today and tomorrow we will wrap up with summaries of sessions, and questions they raised. Today Science Speaks will look at a obstacle for researchers, while presentations pointed to directions for future studies First […]

FDA TB drug approval a milestone, with caveats

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The U.S. Food and Drug Administration’s approval of the first new drug to treat tuberculosis in nearly half a century and the agency’s first use of its accelerated approval process to speed availability of TB medicine comes with cautions, and with a direction of work yet to be done, agency officials and treatment advocates agree. […]

FDA panel finds new type of TB drug effective, raising hopes for treatment of drug-resistant strains

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Dr. Dalene von Delft had a choice between dying  or going deaf, and that was a choice only if the arduous treatment she was undergoing for drug-resistant tuberculosis worked. The South African pediatrician had contracted a resistant strain of the disease caring for patients, and the only potentially effective treatment was showing one of its […]

Drug maker seeks approval for use against multidrug-resistant tuberculosis

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Makers of an investigational tuberculosis drug that has been urged for “compassionate use” approval in South Africa have applied to the European Medicines Agency to market the medicine as part of a combination therapy for multidrug-resistant tuberculosis. “If approved, bedaquiline could be one of the first drugs with a new mechanism of action for tuberculosis […]