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Will survivors of variant P.1 have antibodies that also neutralize B.1.351 — and vice versa?

By Daniel R. Lucey MD, MPH, FIDSA The SARS-CoV-2 variants first described in Manaus, Brazil “P.1.” and in South Africa “B.1.351” share at least five mutations including the antibody-evading changes at amino acids 484 and 417 in the spike protein. Potential cross-protection against the P.1 variant by the new Moderna-NIH B1.351 variant vaccine has been […]

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Recent Posts

The new Moderna/NIH B.1.351-specific vaccine study should add the P.1 variant

By Daniel R. Lucey MD, MPH, FIDSA Two manuscripts from Brazil, newly posted by accomplished researchers on preprint servers, report that the P.1 variant “associated with rapid transmission in Manaus” (by Faria N.  et al.) and reported in the U.S. and 28 other nations, “may escape from neutralizing antibodies generated in response to polyclonal stimulation […]

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In March NIH will start the first variant-specific COVID vaccine study: Will this B.1.351-variant vaccine also induce some immunity to the P.1 variant?

By Daniel R. Lucey MD, MPH, FIDSA On Friday (Feb. 26) National Institute of Allergy and Intections Diseases Director /NIH Dr. Anthony Fauci, announced plans to start vaccine studies for the first time using the variant B.1.351, now dominant in South Africa and present in the United States. It contains the E484K mutation and also […]

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Moderna to test a “multivalent” COVID vaccine as well as single-valent boosters

By Daniel R. Lucey MD, MPH, FIDSA On Wednesday (Feb. 24) Moderna announced a new vaccine strategy against the variant B.1.351 (501Y.V2) now predominant in several nations in southern Africa, and identified in more than 40 nations, as well as multiple U.S. states. Part of this strategy is the first-ever “multivalent” vaccine candidate that “combines […]

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Live Blog Archive

CODEL Video

Click above for a video on our Congressional study tour to Africa, and click here to read more.

HIV

Lancet series highlights a vicious circle of inequities hobbling efforts to end disease spread

Steeped in inequities that include formidable barriers to basic health services for multitudes of its most vulnerable, marginalized and neglected people, the country leading global HIV […]

Tuberculosis

Cost of pandemic includes setbacks to South Africa tuberculosis testing, diagnoses

In the six weeks before South Africa responded its first diagnoses of COVID-19 with the start of physical distancing measures, more than 47,000 people on average […]

Research & Development

CDC urges physicians, parents to be on lookout for AFM, a polio-like illness seen predominately in children

With 2018 data showing highest incidence acute flaccid myelitis since monitoring began, officials say awareness, recognition of rare life threatening condition will be crucial to early […]

Policy

As environmental destruction accelerates the spread of emerging infections, we need to talk

By Karen Carvajal, M.D. Over the course of human history we have come a long way in our fight against the threat of infectious diseases and, […]