Category Archives: TB

China study supports use of repurposed drug, shorter regimen for MDR TB treatment

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Patients treated for multidrug-resistant tuberculosis with an experimental regimen containing a repurposed drug for a year had similar rates of successful outcomes as patients treated with the standard available regimen over the course of 18 months, a study across multiple health facilities in China has found. The only significant difference between the outcomes of the […]

WHO finalizes MDR-TB treatment guidance recommending shift from injections

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Including recommendations that injected drugs with permanent debilitating side effects not be included in longer treatment regimens against multidrug-resistant tuberculosis, and the inclusion of the most recently added drugs, bedaquiline and delamanid in those treatments, the World Health Organization today released updated guidelines for treating TB that does not respond to first line treatments. The […]

WHO releases updated drug-resistant TB guidelines, removing toxic injectables from recommended treatments

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With the release of a “pre-final text” of updated guidelines for treatment of multidrug- and rifampicin-resistant tuberculosis, the World Health Organization made official substantial changes to its recommendations that the agency first announced in August. The changes, announced in a “rapid communication,” which the WHO said was intended to give TB programs time to plan for […]

Findings indicate two newest TB drugs, bedaquiline and delamanid in combination safe, promising for patients with few options

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A study following outcomes of 28 patients with drug-resistant tuberculosis in three countries with high burdens of the disease found what the researchers cite as strong evidence that a combination of the two newest TB drugs could be part of a safe and effective treatment regimen. The  drugs, bedaquiline — which was approved by the […]

Access to medicine, diagnostics and human rights . . . We’re reading how to fight TB

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Just 2 percent of people with the severest cases of drug-resistant TB currently have access to new, more effective treatments that could save their lives – Remember the excitement a couple of years back when the first new kinds of drugs to treat TB to be developed in half a century were approved? When delamanid […]

TB advocates call on organizations, leaders to work together, speed access to existing treatments for drug resistant tuberculosis

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They would like an answer on March 24 When World TB Day next Tuesday commemorates the discovery in 1882 of the bacteria that causes the disease, announcements and op-ed pieces will note the progress that has been made since, and will certainly call for more. A group of 89 organizations that last week sent a […]

TAG’s TB drug guide aims to equip activists

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While the impact of tuberculosis grew over the last decades of the 20th century, with drug resistant forms of the disease and HIV fueling its spread and slowing cures, the drugs used to treat TB have not changed. Bedaquiline and delaminid are the only new TB drugs to have been approved in over forty years, […]

TB drug approvals, distribution deal inches options forward, but MDR TB treatment access still uncertain where needed most

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Last week’s developments in TB treatment included the announcement that bedaquiline, the currently most promising medicine for multi-drug-resistant tuberculosis, will become available to patients in 130 low- and middle-income countries through the Stop TB Partnership’s Global Drug Facility. That good news for multidrug-resistant TB patients, many of whom have run out of other options, was […]

Long road to effective TB treatment hits speed bumps: Regulatory refusal of one TB drug candidate, stalled progress on another

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Momentum toward gathering an effective arsenal of treatment for tuberculosis may have gathered speed in recent years, the 2013 Pipeline Report jointly released by the Treatment Action Group and HIV i-base in June pointed out, yet it falls far short of what people sick and infected with TB worldwide need now. Case in point, the […]

WHO guidance on first new TB treatment in five decades offers hope, emphasizes monitoring

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WHO cites need to prevent new drug resistance, protect first treatment advance in more than 40 years The World Health Organization’s release this week of  interim policy guidelines on the use of bedaquiline  for treatment of multidrug-resistant tuberculosis  offers hope to patients and their physicians running out of options to treat the disease, but the […]